Among various accolades, she won two Primetime Emmys for Dress to Kill and was nominated for a Tony Award for her Broadway performance in A Day in the Death of Joe Egg. Izzard has also worked as a voice actor on films such as Five Children and It (2004), The Wild (2006), The Lego Batman Movie (2017) and the Netflix original series Green Eggs and Ham (2019). She starred in the television series The Riches (2007–2008), and has appeared in numerous films, including Ocean's Twelve (2004), Ocean's Thirteen (2007), Valkyrie (2008), Absolutely Anything (2015) and Six Minutes to Midnight (2020).
Izzard's stand-up comedy tours have included Live at the Ambassadors (1993), Definite Article (1996), Glorious (1997), Dress to Kill (1998), Circle (2000), Stripped (2009), Force Majeure (2013) and Wunderbar (2022).